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Overview & Photos
Rooms
Amenities
About
Reviews
Map

Twenty One Hotel

Vatican City
4-Star Hotel
8.1
Excellent
1681 Reviews
Top Reasons to Book
  • Guests Love It
    Guests give this property a very good rating of 8.1/10
  • Top Rated Location
    Guests rate the location 8.4/10
  • Very Clean
    Guests rate the cleanliness 8.9/10
8.1
Guest Rating
Cleanliness
8.9
Staff
9.1
Location
8.4
Top Amenities
  • Wheelchair accessible
  • Free Wi-Fi
  • Restaurant(s)
  • Non-Smoking Rooms Available
  • Fitness center
Rooms

Twenty One Hotel - Amenities

  • Garden
  • Room Service
  • Safety Deposit Box
  • Air Conditioning
  • Bar
  • 24-Hour Front Desk
  • Express Check-In/Check-Out
  • Elevator
  • Coffee shop
  • Trouser press
  • Packed lunches
  • Heating
  • Fax/photocopying
  • Snack bar
  • Shared lounge/TV area
  • Wheelchair accessible
  • On-site parking
  • Concierge services
  • Designated Smoking Area
  • Free Wi-Fi
  • Hair/Beauty Salon
  • Restaurant(s)
  • Daily Housekeeping
  • Non-Smoking Rooms Available
  • Electric vehicle charging station
  • Emergency cord in bathroom
  • Wine/champagne
  • Fruits
  • Outdoor furniture
  • Smoke alarms
  • Fire extinguishers
  • Staff follow all safety protocols as directed by local authorities
  • Shared stationery such as printed menus, magazines, pens, and paper removed
  • Process in place to check health of guests
  • First aid kit available
  • Cashless payment available
  • Linens, towels and laundry washed in accordance with local authority guidelines
  • Hand sanitizer in guest accommodation and key areas
  • Invoices
  • All plates, cutlery, glasses and other tableware have been sanitized

About

Hotel Features

The Twentyone is a modern boutique hotel on Via Cola di Rienzo, one of Rome's best shopping streets. Castel Sant'Angelo and the historic center are just a pleasant 10-minute walk away. Rooms at the Twentyone Hotel are ultra modern and feature a minimalist décor. They offer an LCD satellite TV, air conditioning, mini-bar, and free WiFi. In the breakfast room located on the roof, where you can enjoy the city view, a breakfast buffet awaits you every morning. Open for lunch and dinner, the on-site restaurant serves traditional Roman and classic Italian dishes and a large selection of wines and champagne. Inside the hotel there is a Starbucks which Guests can access directly and where they can have breakfast. The hotel is in the elegant Prati district, home to the Vatican and Saint Peter's Basilica, which are a 15-minute walk away. Lepanto Metro Station is 1476 feet from the property, while bus links to Roma Termini Train Station are located close by. License Number(s): 058091-ALB-00313, IT

Guest Policies

Check-in
After 15:00
Check-out
Before 11:00
Room Rates
All rates displayed are for double occupancy unless otherwise noted.

Important Information

Please note that parking spaces are limited and subject to availability.

Reviews

8.1
  • Staff
    9.1
  • Cleanliness
    8.9
  • Location
    8.4
  • 10
    Exceptional
    Mar 28, 2026
    Yizhen
    young couple
    Exceptional
    • 8
      Very Good
      Mar 28, 2026
      Irineu
      solo traveller
      Very good

      Location

      Twenty One Hotel
      Rome, IT
      8.4
      Excellent
      Location Score
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      $274
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      $323.01
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      $274
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          $274
          per night
          $323.01
          including taxes & fees
          $274
          per night
          including taxes & fees